Daniel Geschwind

Daniel Geschwind, MD, PhD

A Short Biography:


An elected member of the American Association of Physicians and the National Academy of Medicine, Dr. Geschwind is internationally renowned for identifying gene mutations and potential treatments in autism and other brain diseases. As director of the UCLA Institute for Precision Health, he leads UCLA’s efforts to transform medicine by leveraging the power of genomics, digital health, and big data. He obtained an AB degree from Dartmouth College, and MD and PhD degrees from Yale University School of Medicine. Dr. Geschwind remained at UCLA after his neurology residency and went on to establish a leading Neurogenetics Program and Center for Autism Research. A highly cited Thompson-Reuters Researcher, he has published more than 400 research papers, served on numerous advisory boards, and received multiple awards, including the Derek Denny-Brown Neurological Scholar Award, Autism Speaks Scientific Service Award, and the Brain and Behavior Foundation’s Ruane Prize.

Work Titles

  • CTSI Member
  • CTSI Member Workforce Development
  • UCLA Director, Center for Autism Research and Treatment (CART)
  • Gordon and Virginia MacDonald Distinguished Chair, Human Genetics
  • Professor, Neurology
  • Professor, Psychiatry and Biobehavioral Sciences
  • Co-Director, Center for Neurobehavioral Genetics
  • Professor In-Residence, Tennenbaum Center for the Biology of Creativity
  • Professor In-Residence, Human Genetics
  • Member, Bioinformatics GPB Home Area
  • Member, Brain Research InstituteMember
  • Genetics & Genomics GPB Home AreaMember
  • Neuroscience GPB Home Area

Education

  • M.D., Yale University School of Medicine, 1991
  • Ph.D., Yale University School of Medicine, New Haven, CT, 1984 – 1991
  • A.B., Dartmouth College, 1978 – 1982
  • Fellowship:1995 – 1997 UCLA School of Medicine, Los Angeles
  • Internship:1991 – 1992 UCLA School of Medicine, Los Angeles
  • Residency:1992 – 1995 UCLA School of Medicine, Los Angeles
  • Certifications:1996 American Board of Psychiatry and Neurology

Detailed Biography:

Dr. Daniel Geschwind is the Gordon and Virginia MacDonald Distinguished Professor of of neurology, psychiatry and human genetics at the UCLA School of Medicine. He directs the Neurogenetics Program in the department of Neurology and the Center for Autism Research and Treatment (CART), which is unique in housing 3 Autism Center of Excellence (ACE) Awards from the NIH.

Dr. Geschwind obtained an A.B. in chemistry and psychology (modified) at Dartmouth College, followed by 2 years as a research associate at the Boston Consulting Group. He subsequently obtained his M.D./Ph.D. at Yale School of Medicine (AOA) prior to completing his internship, residency (Neurology), and postdoctoral fellowship at UCLA.

He joined the UCLA faculty in 1997, founding the neurogenetics program. Since then, his laboratory has focused on integrating genetics and genomics with basic neurobiology, relying heavily on computational and bioinformatic methods in addition to wet laboratory experimentation. The ultimate goal is to use these integrative approaches to help develop effective therapeutics for neurologic and psychiatric disorders, including autism and neurodegenerative dementia. One key aspect of his efforts has been the development and application of new analytic methods that elucidate the underlying network organization in multi-dimensional data, permitting integration of genomic and genetic data with phenotype data on a large scale. This has enabled the lab to begin to successfully connect genetic risk for disease in autism to brain circuitry and molecular function both in humans, and in vitro and in vivo model systems. Dr. Geschwind has also put considerable effort into fostering large-scale collaborative patient resources for genetic research and data sharing. He is a strong advocate for data and biomaterial sharing, having provided scientific oversight for the Autism Genetic Resource Exchange (AGRE). He has served on numerous scientific advisory boards, including the Faculty of 1000 Medicine, the Executive Committee of the American Neurological Association, the Neurogenetics Section (founding member and former chair) of the American Academy of Neurology, the NIMH Advisory Council, and the NIH Council of Councils.

He has published over 300 papers and serves on the editorial boards of several journals including Biological Psychiatry, Cell, Neurobiology of Disease, Human Molecular Genetics, Neuron and Science. He received the Derek Denny-Brown Neurological Scholar Award from the American Neurological Association in 2004, the Scientific Service Award from Autism Speaks, a MERIT award from NIMH, the Ruane Prize for Child and Adolescent Psychiatric Research from the Brain and Behavior foundation, and the Taking on Tommorow Innovation Award (for research/scientific breakthrough in autism)” from the Boston Children’s Hospital. He is a member of the American Association of Physicians and a member of the Institute of Medicine of the U.S. National Academies.

Publications:

A selected list of publications:

  • Chaste Pauline, Klei Lambertus, Sanders Stephan J, Hus Vanessa, Murtha Michael T, Lowe Jennifer K, Willsey A Jeremy, Moreno-De-Luca Daniel, Yu Timothy W, Fombonne Eric, Geschwind Daniel, Grice Dorothy E, Ledbetter David H, Mane Shrikant M, Martin Donna M, Morrow Eric M, Walsh Christopher A, Sutcliffe James S, Lese Martin Christa, Beaudet Arthur L, Lord Catherine, State Matthew W, Cook Edwin H, Devlin Bernie   A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity? Biological psychiatry, 2015; 77(9): 775-84. 
  • Chen Jason A, Wang Qing, Davis-Turak Jeremy, Li Yun, Karydas Anna M, Hsu Sandy C, Sears Renee L, Chatzopoulou Doxa, Huang Alden Y, Wojta Kevin J, Klein Eric, Lee Jason, Beekly Duane L, Boxer Adam, Faber Kelley M, Haase Claudia M, Miller Josh, Poon Wayne W, Rosen Ami, Rosen Howard, Sapozhnikova Anna, Shapira Jill, Varpetian Arousiak, Foroud Tatiana M, Levenson Robert W, Levey Allan I, Kukull Walter A, Mendez Mario F, Ringman John, Chui Helena, Cotman Carl, DeCarli Charles, Miller Bruce L, Geschwind Daniel H, Coppola Giovanni   A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy JAMA neurology, 2015; 72(4): 414-22. 
  • Jeste Shafali S, Geschwind Daniel H   Developmental disorders Current opinion in neurology, 2015; 28(2): 89-90. 
  • Peñagarikano Olga, Lázaro María T, Lu Xiao-Hong, Gordon Aaron, Dong Hongmei, Lam Hoa A, Peles Elior, Maidment Nigel T, Murphy Niall P, Yang X William, Golshani Peyman, Geschwind Daniel H   Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism Science translational medicine, 2015; 7(271): 271ra8. 
  • Geschwind Daniel H, State Matthew W   Gene hunting in autism spectrum disorder: on the path to precision medicine The Lancet. Neurology, 2015; 77(9): . 
  • Martinez Refugio A, Stein Jason L, Krostag Anne-Rachel F, Nelson Angelique M, Marken John S, Menon Vilas, May Ryan C, Yao Zizhen, Kaykas Ajamete, Geschwind Daniel H, Grimley Joshua S   Genome engineering of isogenic human ES cells to model autism disorders Nucleic acids research, 2015; 72(4): . 
  • Geschwind Daniel H   Introduction to the year in neurology and psychiatry Annals of the New York Academy of Sciences, 2015; 1338(3): v-vi. 
  • State Matthew W, Geschwind Daniel H   Leveraging genetics and genomics to define the causes of mental illness Biological psychiatry, 2015; 77(1): 3-5. 
  • Legati Andrea, Giovannini Donatella, Nicolas Gaël, López-Sánchez Uriel, Quintáns Beatriz, Oliveira João R M, Sears Renee L, Ramos Eliana Marisa, Spiteri Elizabeth, Sobrido María-Jesús, Carracedo Ángel, Castro-Fernández Cristina, Cubizolle Stéphanie, Fogel Brent L, Goizet Cyril, Jen Joanna C, Kirdlarp Suppachok, Lang Anthony E, Miedzybrodzka Zosia, Mitarnun Witoon, Paucar Martin, Paulson Henry, Pariente Jérémie, Richard Anne-Claire, Salins Naomi S, Simpson Sheila A, Striano Pasquale, Svenningsson Per, Tison François, Unni Vivek K, Vanakker Olivier, Wessels Marja W, Wetchaphanphesat Suppachok, Yang Michele, Boller Francois, Campion Dominique, Hannequin Didier, Sitbon Marc, Geschwind Daniel H, Battini Jean-Luc, Coppola Giovanni   Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export Nature genetics, 2015; . 
  • Lowe Jennifer K, Werling Donna M, Constantino John N, Cantor Rita M, Geschwind Daniel H   Social responsiveness, an autism endophenotype: genomewide significant linkage to two regions on chromosome 8 The American journal of psychiatry, 2015; 172(3): 266-75. 
  • Bakken Trygve E, Miller Jeremy A, Luo Rui, Bernard Amy, Bennett Jeffrey L, Lee Chang-Kyu, Bertagnolli Darren, Parikshak Neelroop N, Smith Kimberly A, Sunkin Susan M, Amaral David G, Geschwind Daniel H, Lein Ed S   Spatiotemporal dynamics of the postnatal developing primate brain transcriptome Human molecular genetics, 2015; . 
  • Yu Huimei, Su Yijing, Shin Jaehoon, Zhong Chun, Guo Junjie U, Weng Yi-Lan, Gao Fuying, Geschwind Daniel H, Coppola Giovanni, Ming Guo-Li, Song Hongjun   Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair Nature neuroscience, 2015; 77(9): . 
  • Chen Jason A, Peñagarikano Olga, Belgard T Grant, Swarup Vivek, Geschwind Daniel H   The emerging picture of autism spectrum disorder: genetics and pathologyAnnual review of pathology, 2015; 10(271): 111-44. 
  • Irimia Manuel, Weatheritt Robert J, Ellis Jonathan D, Parikshak Neelroop N, Gonatopoulos-Pournatzis Thomas, Babor Mariana, Quesnel-Vallières Mathieu, Tapial Javier, Raj Bushra, O’Hanlon Dave, Barrios-Rodiles Miriam, Sternberg Michael J E, Cordes Sabine P, Roth Frederick P, Wrana Jeffrey L, Geschwind Daniel H, Blencowe Benjamin J   A highly conserved program of neuronal microexons is misregulated in autistic brains Cell, 2014; 159(7): 1511-23. 
  • Stein Jason L, de la Torre-Ubieta Luis, Tian Yuan, Parikshak Neelroop N, Hernández Israel A, Marchetto Maria C, Baker Dylan K, Lu Daning, Hinman Cassidy R, Lowe Jennifer K, Wexler Eric M, Muotri Alysson R, Gage Fred H, Kosik Kenneth S, Geschwind Daniel H   A quantitative framework to evaluate modeling of cortical development by neural stem cells Neuron, 2014; 83(1): 69-86. 
  • Tian Yuan, Voineagu Irina, Paşca Sergiu P, Won Hyejung, Chandran Vijayendran, Horvath Steve, Dolmetsch Ricardo E, Geschwind Daniel H   Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome Genome medicine, 2014; 6(10): 75. 
  • Lee Suzee E, Khazenzon Anna M, Trujillo Andrew J, Guo Christine C, Yokoyama Jennifer S, Sha Sharon J, Takada Leonel T, Karydas Anna M, Block Nikolas R, Coppola Giovanni, Pribadi Mochtar, Geschwind Daniel H, Rademakers Rosa, Fong Jamie C, Weiner Michael W, Boxer Adam L, Kramer Joel H, Rosen Howard J, Miller Bruce L, Seeley William W   Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion Brain : a journal of neurology, 2014; 137(Pt 11): 3047-60. 
  • Li Yun, Chen Jason A, Sears Renee L, Gao Fuying, Klein Eric D, Karydas Anna, Geschwind Michael D, Rosen Howard J, Boxer Adam L, Guo Weilong, Pellegrini Matteo, Horvath Steve, Miller Bruce L, Geschwind Daniel H, Coppola Giovanni   An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy PLoS genetics, 2014; 10(3): e1004211. 
  • Pinto Dalila, Delaby Elsa, Merico Daniele, Barbosa Mafalda, Merikangas Alison, Klei Lambertus, Thiruvahindrapuram Bhooma, Xu Xiao, Ziman Robert, Wang Zhuozhi, Vorstman Jacob A S, Thompson Ann, Regan Regina, Pilorge Marion, Pellecchia Giovanna, Pagnamenta Alistair T, Oliveira Bárbara, Marshall Christian R, Magalhaes Tiago R, Lowe Jennifer K, Howe Jennifer L, Griswold Anthony J, Gilbert John, Duketis Eftichia, Dombroski Beth A, De Jonge Maretha V, Cuccaro Michael, Crawford Emily L, Correia Catarina T, Conroy Judith, Conceição Inês C, Chiocchetti Andreas G, Casey Jillian P, Cai Guiqing, Cabrol Christelle, Bolshakova Nadia, Bacchelli Elena, Anney Richard, Gallinger Steven, Cotterchio Michelle, Casey Graham, Zwaigenbaum Lonnie, Wittemeyer Kerstin, Wing Kirsty, Wallace Simon, van Engeland Herman, Tryfon Ana, Thomson Susanne, Soorya Latha, Rogé Bernadette, Roberts Wendy, Poustka Fritz, Mouga Susana, Minshew Nancy, McInnes L Alison, McGrew Susan G, Lord Catherine, Leboyer Marion, Le Couteur Ann S, Kolevzon Alexander, Jiménez González Patricia, Jacob Suma, Holt Richard, Guter Stephen, Green Jonathan, Green Andrew, Gillberg Christopher, Fernandez Bridget A, Duque Frederico, Delorme Richard, Dawson Geraldine, Chaste Pauline, Café Cátia, Brennan Sean, Bourgeron Thomas, Bolton Patrick F, Bölte Sven, Bernier Raphael, Baird Gillian, Bailey Anthony J, Anagnostou Evdokia, Almeida Joana, Wijsman Ellen M, Vieland Veronica J, Vicente Astrid M, Schellenberg Gerard D, Pericak-Vance Margaret, Paterson Andrew D, Parr Jeremy R, Oliveira Guiomar, Nurnberger John I, Monaco Anthony P, Maestrini Elena, Klauck Sabine M, Hakonarson Hakon, Haines Jonathan L, Geschwind Daniel H, Freitag Christine M, Folstein Susan E, Ennis Sean, Coon Hilary, Battaglia Agatino, Szatmari Peter, Sutcliffe James S, Hallmayer Joachim, Gill Michael, Cook Edwin H, Buxbaum Joseph D, Devlin Bernie, Gallagher Louise, Betancur Catalina, Scherer Stephen W   Convergence of genes and cellular pathways dysregulated in autism spectrum disorders American journal of human genetics, 2014; 94(5): 677-94. 
  • Jeste Shafali S, Geschwind Daniel H   Disentangling the heterogeneity of autism spectrum disorder through genetic findings Nature reviews. Neurology, 2014; 10(2): 74-81. 
  • Naj Adam C, Jun Gyungah, Reitz Christiane, Kunkle Brian W, Perry William, Park Yo Son, Beecham Gary W, Rajbhandary Ruchita A, Hamilton-Nelson Kara L, Wang Li-San, Kauwe John S K, Huentelman Matthew J, Myers Amanda J, Bird Thomas D, Boeve Bradley F, Baldwin Clinton T, Jarvik Gail P, Crane Paul K, Rogaeva Ekaterina, Barmada M Michael, Demirci F Yesim, Cruchaga Carlos, Kramer Patricia L, Ertekin-Taner Nilufer, Hardy John, Graff-Radford Neill R, Green Robert C, Larson Eric B, St George-Hyslop Peter H, Buxbaum Joseph D, Evans Denis A, Schneider Julie A, Lunetta Kathryn L, Kamboh M Ilyas, Saykin Andrew J, Reiman Eric M, De Jager Philip L, Bennett David A, Morris John C, Montine Thomas J, Goate Alison M, Blacker Deborah, Tsuang Debby W, Hakonarson Hakon, Kukull Walter A, Foroud Tatiana M, Martin Eden R, Haines Jonathan L, Mayeux Richard P, Farrer Lindsay A, Schellenberg Gerard D, Pericak-Vance Margaret A, Pericak-Vance Margaret A, Albert Marilyn S, Albin Roger L, Apostolova Liana G, Arnold Steven E, Barber Robert, Barnes Lisa L, Beach Thomas G, Becker James T, Beekly Duane, Bigio Eileen H, Bowen James D, Boxer Adam, Burke James R, Cairns Nigel J, Cantwell Laura B, Cao Chuanhai, Carlson Chris S, Carney Regina M, Carrasquillo Minerva M, Carroll Steven L, Chui Helena C, Clark David G, Corneveaux Jason, Cribbs David H, Crocco Elizabeth A, DeCarli Charles, DeKosky Steven T, Dick Malcolm, Dickson Dennis W, Duara Ranjan, Faber Kelley M, Fallon Kenneth B, Farlow Martin R, Ferris Steven, Frosch Matthew P, Galasko Douglas R, Ganguli Mary, Gearing Marla, Geschwind Daniel H, Ghetti Bernardino, Gilbert John R, Glass Jonathan D, Growdon John H, Hamilton Ronald L, Harrell Lindy E, Head Elizabeth, Honig Lawrence S, Hulette Christine M, Hyman Bradley T, Jicha Gregory A, Jin Lee-Way, Karydas Anna, Kaye Jeffrey A, Kim Ronald, Koo Edward H, Kowall Neil W, Kramer Joel H, LaFerla Frank M, Lah James J, Leverenz James B, Levey Allan I, Li Ge, Lieberman Andrew P, Lin Chiao-Feng, Lopez Oscar L, Lyketsos Constantine G, Mack Wendy J, Martiniuk Frank, Mash Deborah C, Masliah Eliezer, McCormick Wayne C, McCurry Susan M, McDavid Andrew N, McKee Ann C, Mesulam Marsel, Miller Bruce L, Miller Carol A, Miller Joshua W, Murrell Jill R, Olichney John M, Pankratz Vernon S, Parisi Joseph E, Paulson Henry L, Peskind Elaine, Petersen Ronald C, Pierce Aimee, Poon Wayne W, Potter Huntington, Quinn Joseph F, Raj Ashok, Raskind Murray, Reisberg Barry, Ringman John M, Roberson Erik D, Rosen Howard J, Rosenberg Roger N, Sano Mary, Schneider Lon S, Seeley William W, Smith Amanda G, Sonnen Joshua A, Spina Salvatore, Stern Robert A, Tanzi Rudolph E, Thornton-Wells Tricia A, Trojanowski John Q, Troncoso Juan C, Valladares Otto, Van Deerlin Vivianna M, Van Eldik Linda J, Vardarajan Badri N, Vinters Harry V, Vonsattel Jean Paul, Weintraub Sandra, Welsh-Bohmer Kathleen A, Williamson Jennifer, Wishnek Sarah, Woltjer Randall L, Wright Clinton B, Younkin Steven G, Yu Chang-En, Yu Lei  Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study JAMA neurology, 2014; 71(11): 1394-404. 
  • Fogel Brent L, Lee Hane, Deignan Joshua L, Strom Samuel P, Kantarci Sibel, Wang Xizhe, Quintero-Rivera Fabiola, Vilain Eric, Grody Wayne W, Perlman Susan, Geschwind Daniel H, Nelson Stanley F   Exome sequencing in the clinical diagnosis of sporadic or familial cerebellar ataxia JAMA neurology, 2014; 71(10): 1237-46. 
  • Chaste Pauline, Sanders Stephan J, Mohan Kommu N, Klei Lambertus, Song Youeun, Murtha Michael T, Hus Vanessa, Lowe Jennifer K, Willsey A Jeremy, Moreno-De-Luca Daniel, Yu Timothy W, Fombonne Eric, Geschwind Daniel, Grice Dorothy E, Ledbetter David H, Lord Catherine, Mane Shrikant M, Martin Donna M, Morrow Eric M, Walsh Christopher A, Sutcliffe James S, State Matthew W, Martin Christa Lese, Devlin Bernie, Beaudet Arthur L, Cook Edwin H, Kim Soo-Jeong   Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2 Autism research : official journal of the International Society for Autism Research, 2014; 7(3): 355-62. 
  • Fogel Brent L, Cho Ellen, Wahnich Amanda, Gao Fuying, Becherel Olivier J, Wang Xizhe, Fike Francesca, Chen Leslie, Criscuolo Chiara, De Michele Giuseppe, Filla Alessandro, Collins Abigail, Hahn Angelika F, Gatti Richard A, Konopka Genevieve, Perlman Susan, Lavin Martin F, Geschwind Daniel H, Coppola Giovanni   Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 Human molecular genetics, 2014; 23(18): 4758-69. 
  • Geschwind Daniel, Nestler Eric J   Neurodegenerative dementias: connecting psychiatry and neurology through a shared neurobiology Biological psychiatry, 2014; 75(7): 518-9. 
  • Wright Megan C, Mi Ruifa, Connor Emmalynn, Reed Nicole, Vyas Alka, Alspalter Manula, Coppola Giovanni, Geschwind Daniel H, Brushart Thomas M, Höke Ahmet   Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(5): 1689-700. 
  • Correia Catarina T, Conceição Inês C, Oliveira Bárbara, Coelho Joana, Sousa Inês, Sequeira Ana F, Almeida Joana, Café Cátia, Duque Frederico, Mouga Susana, Roberts Wendy, Gao Kun, Lowe Jennifer K, Thiruvahindrapuram Bhooma, Walker Susan, Marshall Christian R, Pinto Dalila, Nurnberger John I, Scherer Stephen W, Geschwind Daniel H, Oliveira Guiomar, Vicente Astrid M   Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders Molecular autism, 2014; 5(1): 28. 
  • Werling Donna M, Lowe Jennifer K, Luo Rui, Cantor Rita M, Geschwind Daniel H   Replication of linkage at chromosome 20p13 and identification of suggestive sex-differential risk loci for autism spectrum disorder Molecular autism, 2014; 5(1): 13. 
  • Buxbaum Joseph D, Bolshakova Nadia, Brownfeld Jessica M, Anney Richard Jl, Bender Patrick, Bernier Raphael, Cook Edwin H, Coon Hilary, Cuccaro Michael, Freitag Christine M, Hallmayer Joachim, Geschwind Daniel, Klauck Sabine M, Nurnberger John I, Oliveira Guiomar, Pinto Dalila, Poustka Fritz, Scherer Stephen W, Shih Andy, Sutcliffe James S, Szatmari Peter, Vicente Astrid M, Vieland Veronica, Gallagher Louise   The Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses Molecular autism